Enter the exciting world of Frank Bigelow, an accountant who also notarizes stuff. His girlfriend/assistant Paula wants to get married, and is being super sarcastically naggy about it, so he decides to go to San Francisco to get a break from her. While out drinking, a mysterious stranger poisons his cocktail. As he retraces his steps to find out who poisoned him and why, he uncovers a web of crime, infidelity, and jazz clubs. With the help of loyal Paula, he discovers that a couple of years ago he notarized a bill of sale for an iridium shipment, and now the Mafia wants him dead. Well! He’s only got 48 hours to figure everything out before the poison kills him and, in the process, realizes he truly loves Paula. His story unfolds at the police station in flashback so we the audience slowly learn that, as he tells his tale, he is in actuality already D.O.A (dead on arrival).