In this first episode of Richard Hammond's Brain Reaction, Victoria Coren Mitchell and teammate London Hughes go head to head with Johnny Vegas and Henning Wehn. And shining the light of science on proceedings is comedian and brain box Ria Lina.
| Name | Type | Role | |
|---|---|---|---|
| London Hughes | Guest Star | Self | |
| Henning Wehn | Guest Star | Self | |
| Ryan Sidebottom | Guest Star | Self |