In episode one Richard Dawkins thinks it is time for science to stop sitting on the fence. He meets leaders from the Christian, Jewish and Muslim religions to find out how their beliefs fit with modern science's extraordinary knowledge of our world and the wider universe. Dawkins accuses the religious establishment of preying on people's desire to believe in a greater being; abusing reason and humanity in the process. Ultimately he asks how they can defend what religion has done, and is doing to us?