The introductory sequence shows Poemy fighting shadowy figures of various other magical girls such as Usagi Tsukino from Sailor Moon, Tickle from Majokko Tickle, Utena from Revolutionary Girl Utena, Megu and Non from Majokko Megu-chan, Mahoro from Mahoromatic, Sakura Kinomoto from Cardcaptor Sakura, and the considered first magical girl in Japanese animation, Sally, from Sally, the Witch.
At the start of a new school year the over-energetic Poemy Watanabe is introduced, along with her adoptive parents Nabeshin and Kumi-Kumi. Poemy rushes to the school to be the first there, at the same time she repeatedly proclaims her desire to become a successful voice actress. At the school, Poemy's best girl friend, Futaba Aasu, is presented as Poemy's biggest supporter and in fact perennially sexually attracted to her. Back from school, Poemy and Futaba realize the horror of finding Poemy's parents and their robot dog crucified by Alien #1, an extraterrestrial assassin with peculiar genitalia. Her home destroyed, Poemy moves in with Futaba and her six sisters. Later, a massive alien robot attacks the city, whereupon it turns out that Futaba and her sisters are actually a secret team of super-powered heroines dedicated to defending the Earth, also known as Sol III. Unfortunately, the Aasu sisters' magic is strictly defensive, so they are unable to defeat the rampaging robot. Meanwhile, Poemy obtains a talking, magic fish that when used as a magic wand transforms her into Puni Puni Poemy, a powerful magical girl. After the typical transformation, however, she promptly throws away her wand, forgoes the use of magic, and attacks the robot with her bare hands.
Poemi Watanabe è una ragazzina piena di energie. Il suo sogno è quello di diventare una grande doppiatrice, e vuole sempre dimostrare il suo impegno in tutto ciò che fa. Ma quando i suoi genitori, Nabeshin e Kumi-Kumi, vengono uccisi dagli alieni è costretta a rifugiarsi a casa della sua amica Futaba.
ワタナベぽえみは声優を夢見る元気な4年生。おうちは寒風吹きすさぶ日本海沿岸で浜茶屋を営んでいる（かなり無理）。
はっきしいってビンボーだけど、アフロなナイスガイのパパと鍼灸師のママの愛に育まれ、幸せな生活を送っていた。
が、好事魔多し！突如現れた謎のエイリアンがワタナベ家を襲い、両親が殺されてしまう。
突然の悲劇に呆然としながらも復讐なんざ後回しにして、とりあえず住むところを探すぽえみ。
同情したクラスメイトのふたばは、自分の家にぽえみを引き取ることにするが、ふたばの家族は地球を守る地球防衛家族「我々守（アース）シスターズ」であった。
いっぽう、エイリアンの侵略は着々と進展し、町は巨大ロボに攻撃されていた。我々守家の七人姉妹は現場に向かうが、圧倒的な敵の攻撃に歯が立たない。
と、そこに現れたぽえみが・・・！！
