In the first episode of the series, the end of Sydney's Lockout Laws spells chaos for the Emergency Department. St Vincent's Hospital's Emergency Department is located in the heart of the city's bustling nightlife precinct. It's the first weekend in seven years that the strict drinking and nightclub laws designed to curb alcohol-related violence have been lifted. For Emergency nurses Darren, Yoon and Carly, that means a steady flow of drug-and-alcohol-affected patients are quickly filling the ward. An intoxicated man is brought in from Kings Cross bleeding from the head and Yoon is concerned he may have a brain injury. The youngest drug-affected patient of the night, an 18-year-old woman, is rushed in by ambulance, unconscious and showing signs of serotonin syndrome - a potentially fatal condition. A few floors up in theatre, perioperative nurse Nakita is scrubbed in for a complicated heart surgery for a 43-year-old patient, who is having a mitral valve replaced.
Emergency nurses fight to revive a woman in cardiac arrest; a patient with terminal lung failure undergoes a risky lung transplant and a breech birth has midwife Lucy braced for resuscitation.
It's the football season, and the Emergency Department at St Vincent's is dealing with shoulder injuries.
The team in Emergency brace themselves for an incoming patient who jumped in front of a train. Meanwhile, it's Intensive Care Nurse Ali's last shift before she moves to Edinburgh.
A 21-year-old woman is rushed to Emergency after being kicked in the face by a horse and nurse Hannah comforts an elderly man who has suffered a stroke.
A graduate midwife is put to the test and the hospital rolls out the first doses of the COVID-19 vaccine to medical staff.