Five pretty nurse students and their boss Leonore are the focus of this TV series. They are all living together in a villa called "Nightingale House" located in Los Angeles. Leonore has a complicated private relation to one of the physicians (Barry Newman). Allyson, the sexy blonde, is always falling for the wrong guy. There is also Yolanda, the underprivileged minority student Yolanda and Samantha who has problems to look after her illegitimate daughter Megan and study as hard as the others at the same time. Becky is the naive girl from the country side.