Staci faces a difficult task involving guest Michael J. Fox and a stunt with a cannon. Meanwhile, Jim Gaffigan desperately wants to promote his new energy drink on the show.
Tim Gunn stops by unexpectedly, so the staff must juggle guests. Meanwhile, Todd asks Debra Messing to film a video while channeling her old sitcom character; and Randy and Marcus pitch their invention to Mark Cuban.
Jason Biggs acts differently on a return appearance, surprising the staff. Meanwhile, Beth Stern promotes animal adoption by bringing kittens, but trouble arises when one cat disappears.
Staci tries to convince transgender celebrity GiGi Gorgeous to go on a date with Jimmy; Ana pitches her makeup line and wants Stephanie March to be her new spokesperson; Janeane Garofalo is dismayed by Jimmy's sexist sketch.
Chef Mario Batali tries to aid Staci as she struggles through a horrible bout of irritable bowel syndrome; journalist George Stephanopoulos schools Penny on ISIS, an organization she believes is trying to recruit her.
Jimmy wants a biopic made about his life, and he wishes to be portrayed by Paul Rudd. Meanwhile, Wendy Williams strikes up an unexpected bond with someone over wigs.
Staci interviews for an Executive Producer position at Wendy Williams and seriously considers leaving Nightcap. Mariska Hargitay has agreed to be eaten by an anaconda on air, and Todd gets to direct his first shoot starring Rosie Perez—until Joel Schumacher intervenes.
Debra Messing fills in at the last minute and gets too close for Staci's comfort,arranging a "girls spa day" for the two in her dressing room. Davis has his hands full with Brendan Fraser, who wants to try his hand at musical comedy and debut a very offensive song on Nightcap.
TV's favorite dad Bob Saget only wants to talk about his obsession with a Japanese collectible toy; comic Carrot Top convinces Todd to capitalize on an unfortunate nickname earned after an on-air flub.
There's more chaos backstage than normal when Jimmy's new girlfriend Christie Brinkley demands he quit Nightcap. Bethenny Frankel is saving her voice for a speaking engagement and forces Penny to do her dirty work. David Hasselhoff spends the day telling embarrassing stories about his nephew, Nightcap's own hair and makeup guru, Marcus.
Staci pitches a movie to director J.J. Abrams; Penny begs Staci to save the show; Staci offers up TV show host Rachael Ray as an appealing new love interest for fame-hungry Christie Brinkley; actor Mark Hamill shows up to discuss Staci's new film.