Bad Mouse and his rodent followers steal the city mint.
Magnet Man threatens to use his giant magnet to pull the city into the river unless he is paid a very big ransom.
To pull off the crime of the century, Anthead steals computers to help him plan one.
Mr. and Mrs. Van Pire are hypnotizing millionaires to sell them their fortunes and then turning them into bats.
Goldteeth and his sidekick Doctor Decay plan to steal a gold plated satellite that is orbiting outer space.
Baby Man and his nanny henchwomen are making City officials act like babies by spraying them with a secret formula.
Sick of being beaten by Mighty Man and Yukk, the villainous Glue Man hatches a plan to steal chemicals that will create a formula to turn himself into Super-Glue Man upon obtaining a scientist named Dr. Stickol.
Miss Make-Up, the most beautiful criminal that ever lived, plans to steal a scroll that contains Cleopatra's beauty secrets.
Madame Sleep and her henchmen Lazy and Tired steal King Ledus' ring. She plans to use the ring which is a key to unlock the vault at the Lagovian Embassy, steal the Lagovian Lion Statue and hold it for a ransom of $10,000,000,000.
To infiltrate Coach Crime's gang of thieves and figure out who his real identity is, Mighty Man and Yukk pose as safecrackers.
The Rooster steals an anti-gravity machine which he uses to commit numerous dastardly crimes in order to make himself Public Enemy #1.
The Time Keeper and his henchmen Minute Man and Second Hand Rose are freezing time. They then commit crimes resulting in an unstoppable crime spree.
The maniacal Handhead tries to force a movie studio to replace their actress Paulette with his girlfriend Billie by sabotaging their latest movie.
In a plot to discredit Mighty Man and Yukk, Dr. Rufus T. Gadgets sets up his own crimes so that he can be the hero of the city.
Baron Brute steals an amnesia machine and plans to use it to win a space shuttle contract by sabotaging his opponent.
Mighty Man and Yukk encounter Beach Bum, a villain who uses his surfing talents and advanced technology to steal anything valuable including King Neptune's golden trident.
Fishface uses his trained dolphins to capture millionaires on their yachts and has his henchmen disguise themselves as them.
A cat burglar named Catman uses his trained his pet lion and black panther to steal the worlds largest diamond.
A scientist named Dr. Lash thaws out a Viking warrior named Kragg the Conqueror and his hound. He then plans to use them to abduct the mayor, the police chief, and Mighty Man.
Miro The Mentalist uses a mindreading machine that enables him to steal valuable information from the brains of his victims.
Fed up with guard dogs spoiling his crimes, a small-time criminal becomes the Dogcatcher, luring and capturing dogs with a sonic whistle so he can eliminate every dog on Earth, including Yukk.
Future Man, a fully evolved human with futuristic powers, plans to turn the whole of mankind into cavemen.
Camera Man uses his 3-D camera to travel through any television in the city and commit robberies.
Krime Klown uses his Krime Kazoo to turn the citizens into his circus henchmen.
Copycat and his henchman Ivan plot to steal the fortune and money belt of oil tychoon Bucks Galore.
Former TV villain Nefario creates a super suit which enables him to stay one step ahead of Mighty Man and Yukk while he is committing a series of crimes.
Marble Man uses a device to bring statues to life in a plot to drive out the citizens and claim the city for themselves.
Evila the Witch enchants the city's gems into following her back to her house.
Dr. Locust attempts to steal three ancient Chinese junks that once combined creates a robotic warrior.
Stanley Johnson is set to inherit a fortune if he spends the night in a haunted house. The only problem is the Creep and his henchman Clyde plan to kidnap Stanley so that the Creep inherits the money himself.
Doctor Icicle and his sidekick Frosty are kidnapping renowned scientists in order to build a super freezing machine that will freeze the sun.
An evil professor named Sanfon Vulch creates Glop, a monster that can eat its way though anything. Glop is sent to Brandon Brewster's house to eat through his safe and steal a set of valuable blueprints.