Edith's liberal cousin, Maude Findlay, arrives to help in caring for a flu-ridden Archie and Mike.
Archie and Edith visit Maude's house for Carol's wedding to David Green, a Jewish man. Archie doesn't want to go, and Carol doesn't want him there. Archie is invited to the bachelor party, but declines the invitation, and ends up staying at the hotel, where the bachelor party is held (which he doesn't know). Archie calls the police because the party is too loud. Edith stays for the bridal shower. After David and Walter return from the bachelor party, David and Carol fight over their differences in opinion regarding women's roles. The wedding is off, much to Maude's dismay.
Carol's odd behavior leads Maude to believe she's having an affair. When Maude learns Carol is really seeing a psychiatrist, she is determined to get to the bottom of the situation and find out why her daughter needs therapy. Maude promptly makes an enexpected visit to Carol's psychiatrist but soon finds herself being analyzed.
Carol is dating Russell Asher, a dashing writer, who just happens to have once dated and later jilted Maude. This leads Maude to do her best to warn Carol of Russell's egotistical ways. However, Carol refuses to heed Maude's warnings and continues to date him, even spending the night with him which turns into a disaster.
Maude throws a fund raising party for a black militant leader and invites rich white liberals but doesn't tell them it is a fund raising party. Meanwhile, Maude does her best to get a black couple to attend the party but must settle for a disguised Florida. Arthur doesn't help the situation either after prescribing tranquilers to Maude who during the party mixes them with alcohol.
Maude and Walter are scheduled to play cards one evening with some friends but Maude is anything but in a card playing mood. Especially since, she just came back from a doctor's appointment with some shocking news. At 47 years old, Maude has become pregnant. Now the hard part, breaking the news to Walter.
After Carol suggests an abortion, Maude begins heavy debating over the pros and cons of having a baby at her age. Walter's "what-ever-you-want" attitude has Maude having a problem deciding wheather or not to keep the baby. Ultimately, Maude takes into consideration everyone's opinion and makes a final decision, she decides not to have the baby.
Maude pulls out all her high school memorabilia as she awaits the arrival of an old school friend, Phyllis Nash, who was nicknamed both "Bunny" because of an overbite and "Mousie" because of her looks. However, Maude is stunned and becomes envious when she discovers Phyllis is now a beauty with a career to match.
As a 19-year-old faces a lengthy prison sentence for marijuana possession, Maude and a group of middle-aged housewives plan a protest at a police station. The plan is to get arrested for possession and Maude is supposed to provide the pot. However, trying to get her hands on some, proves to be problematic.
Walter and Maude go to Massachusetts for an appliance seller's convention. When their reservations at a upscale hotel are botched, they must share a shabby motel. This is when a squabble ensues when Maude tries to confide in Walter the angst she has over not having any meaning in her life and the troubles she's been having trying to find a job because she's a woman.
Walter and Maude are planning on taking a second honeymoon to Italy, however, the day their plane leaves, Maude gets a tetnus shot which results in a rash. She immediatley hotfoots it down to the doctors office where she encounters a busy preoccupied doctor who perscribes her medication but doesn't advise her on how to take it, resulting in an overdose, cancellation of the honeymoon and a possible malpractice suit.
After a fire breaks out in his home, Arthur moves in with the Findlays and immediately works over Maude's nerves. Not only does Arthur keep Walter up all night playing card games, but he gives Florida work to do and insists Maude prepare his food in a certain way. Pretty soon, Maude insists that Walter throw him out.
An old friend of Maude's comes for a visit with news of a feud between herself and her daughter. This leads Maude to go all out and try to reconcile the two but a generation gap and financial matters are working against her attempts. Meanwhile, at the same time, Maude tries to matchmake her friend up with Arthur.
Maude and Walter prepare for a dinner party at Cliff and Joanna Naylor's home. However, while they are getting ready, they discuss and bicker about Cliff's apparent crush on Maude and how she is flattered by him, that is until Walter breaks the news that Cliff is having an affair with someone else at the country club.
After a wild evening of drinking, Maude, Walter and Arthur awake to discover some oddities. First, Maude and Arthur shared a bed, second the guys trashed the living room and third, Walter made an obscene phone call to Maude's mother. Carol suggests that perhaps Walter has a drinking problem but he refuses to face that fact. Maude and Walter later get into a big argument while they are both drunk and Walter slaps her.
After giving Maude a black eye, Walter continues to drink. Later, Arthur sends over a recovering alcoholic to talk some sense into Walter who adamantly refuses help. When Walter discovers Maude got rid of all the alcohol, he goes ballistic and she locks him in the closet. That's when Carol makes an announcement, she's taking Phillip and is moving out
At age 47 and recently divorced, Vivian begins her single career (a.k.a. husband search) by getting a face-lift; her new face receives plenty of cheers from Carol and Walter, but only jeers from Maude. This leads Vivian to state the obvious, Maude is jealous and would like a face-lift herself. Maude finally decides to have one and intends to keep it a secret from Walter until she has it done.
Carol does her best to try to keep Walter in the house as anticipation mounts for Maude's return from a 3-week stay in Boston. For which, following Vivian's lead, Maude too got a face-lift. There is only one problem: Walter doesn't notice the difference! As usual, all hell breaks loose and Walter and Maude have yet another argument.
The lazy furnace repairman, Whitnauer, has been showing an interest in Florida and she doesn't quite know what to do about his advances. This situation ultimately causes marital problems between Florida and her husband, Henry, when he catches her dancing with the man. Meanwhile, Maude and Walter are finding it hard to get Whitnauer to hurry it up on the furnace.
Maude is sky high now that she has a part-time job as a real estate agent. However, things on the home-front are not so happy as Walter, a self proclaimed old fashioned man, is not used to coming home and not having Maude to cook for him and tell his problems too. Thus, he orders her to quit her job.
Maude's constant matchmaking for Vivian has her fed up, especially since all the men have one thing on their mind. This leads Vivian to give up on men and settle for a 70-year old retired general. However, when Maude learns this, she becomes determined to show Vivian that she can do better and fixes her up with Arthur.
Maude is putting together a charity musical to raise money for a library. The musical is set to be in the style of burlesque, however, Arthur is having a problem with almost every sketch that is planned, accusing them of being distasteful and in some cases pornographic. Maude is quickly faced with an ultimatum, Arthur's way or no musical.
As their impending nuptials draw near, Maude decides to give Carol and Chris their wedding gift early. They are both certainly surprised to find out that Maude has put a down payment on a house for them but the even bigger surprise is that the house is located right across the street. Immediately this sparks family tension between mother and daughter and future husband and wife.
Arthur and Vivian have been dating regularly and Vivian has had it with Arthur's constant mentioning of his late wife, Agnes. This leads to yet another argument between Maude and Walter over her late husband, Albert. However, by the end of the evening, Vivian makes an exciting announcement, Arthur and her are engaged.
Maude finds a wallet on the street that belongs to a man, known for his infidelities. After Walter declares a wallet is a place of privacy for all men, she snoops into his wallet. This triggers a series of mistaken identities when she confronts a woman, Norma, whom she thinks is carrying on an affair with Walter.
Walter throws Maude a surprise birthday party and she truly is surprised but unhappy about turning another year older. Tired of the men going off by themselves and the women going off by themselves, Maude makes Walter promise to not leave her side the entire evening. However, he soon breaks his promise and Maude goes into her bedroom and refuses to come out.
Maude suggests a romantic winter wedding for Arthur and Vivian, so they all head to Vermont. However, Arthur and Vivian's wedding plans run into trouble as the wedding party gets stranded at a train station during a blizzard. Once there, Maude confronts Arthur about the cold feet he has over marrying Vivian.
After Henry, Florida's husband, gets a job promotion, she must tell Maude she's leaving to become a full-time housewife. Maude is heartbroken and is reluctant to hire anyone new but as applicants for the new job come in, Maude finds something wrong with each one. Finally, at the end of the day, Maude must say goodbye to Florida.
Walter is a nervous wreck as the Findlays get a tax audit but the tax auditor, Harvey Clarke, turns out to be a man who tried to rape Maude 31 years ago in Boston, Massachusetts. When she tells Walter he doesn't want to do anything about it, but Maude can't let it go and decides to refresh his memory.
Arthur gives Walter a stock tip which causes Walter to lose $3,700. Walter, angry at Arthur, insists on being angry with Arthur for saying it was a sure thing. Later, when Walter finds out Arthur didn't invest in the stock himself, questions arise about his financial situation, which leads to a huge blowup between Walter, Maude, Vivian and Arthur.
Francie Potter, the teenage house-guest from the ghetto returns again, this time asking for money to run away from home. In a plot with her boyfriend, Francie worms her way into Maude's wallet using a bogus story about her drunken father who abuses her and she now want to escape to become a rock and roll star.
As part of a publicity tour for a new movie, John Wayne makes a stop in Tuckahoe, to visit Arthur, his number one fan. However, when the ceiling caves in at the Harmons, Arthur talks Maude into hosting the party. Maude decides to have a verbal shootout with the Duke about woman's lib but finds her tongue tied when she actually meets him.
Maude becomes concerned when Walter begins smoking a pipe and wearing high heeled shoes. She suggests that perhaps he's going through male menopause. However, what really concerns both her and Arthur is when they catch Vivian and Walter sharing a kiss. This obviously leads to yet more marital strife between the Findlays and the Harmons.
With Florida gone, Maude has finally decided to hire a new housekeeper. She is excited with the fact that the new one, Mrs. Naugatuck is British but quickly the two of them clash over gender roles, as Mrs. Naugatuck insists on calling Walter the master of the house and begins to pamper his every need.
Maude and Vivian go out for drinks one evening, while Arthur and Walter go away for a golfing weekend. The two girls soon compare notes and discover that an old flame who once dated both of them has sent them each a post card saying he'll be in town. The two girls quickly get drunk while debating over who he finds more attractive.
Walter and Arthur return from an outing in Canada with a batch of fresh fish and a lack of interest in their eager wives. However, Walter has one very important interest, to move the family to the Canadian wilderness. Maude is dead set against the notion, but her reverse psychology fails and Walter ends up trying to sell his business.
Maude is having a restless night, she can't sleep because she has something very important on her mind and wants to tell Walter about it, but he's too busy worrying about the blizzard outside and his end of the summer sale scheduled for the next day. So she decides to just drop the bomb, her doctor has told her that she should have a hysterectomy.
Vivian is throwing a party and she is a nervous wreck, luckily she has Maude to help her. Things get worse when her maid refuses to serve during the event so, Maude extends a hand and gets Mrs. Naugatuck to help out. However, after all that, Maude is in for a shock, Walter and her are not invited to the party.