Nick Lachey returns to his hometown of Cincinnati to open a bar with his brother and 98 Degrees bandmate Drew; the brothers conduct important business research by going on a pub crawl.
Nick and Drew visit a local brewery for help in determining the beer selection in their bar; a keg party decides which of the brothers' signature beers will be featured at their business.
The brothers get opinions on possible menu items for the bar by holding a taste test during a Cincinnati Bengals tailgate; Nick's wife, Vanessa, pays a surprise visit to Ohio.
After a challenge from their friends to bartend on opening night at their bar, Nick and Drew take bartending classes in order to learn the necessary skills. Additionally, the guys are selected as Grand Marshals of Cincinnati's Oktoberfest celebration and enter various competitions at the event.
With Nick stuck in New York, Drew takes some friends on a rollicking trip to Kentucky's Bourbon Trail, where he purchases an expensive barrel of bourbon. When he surprises Nick with it, the brothers don't exactly see eye to eye.
With the bar opening only two weeks away, Nick and Drew must hire another bartender; Drew works on a secret project.
Nick and Drew work through the night to prepare the bar for opening; the brothers get the key to the city from the mayor; the doors to Lachey's are officially opened.
Drew holds down the fort at the bar in Cincinnati all by himself, until his mother volunteers to help out.
Problems arise when Nick and Drew each book parties on the same night in the bar's private event space.
Nick considers relocating his family to Cincinnati when he and Drew are offered the opportunity to host a weekly radio show at the bar.