Welcome to the crazy and cooky world of Kathy Griffin, the D-List celebrity everyone knows as "that red-head chick." Despite living a life of low-celeb status, where she assists in judging a drag queen beauty pageant, attempts to recruit celebrities to come to her annual Toys for Tots fundraiser, tries to get a free sofa for her in-the-works A-List house, and "bombs" with her raunchy comedy at a stuffy charity dinner, Kathy gets all of the support she needs from her parents, her husband, her wonderful assistant, her two "best gays," and her live-in gay visionary, Mike, who is designing Kathy's house for next-to-free in exchange for the publicity that will come with the house. Kathy's life proves that you don't need to be Nicole Kidman in order to enjoy yourself.
| Name | Type | Role | |
|---|---|---|---|
| Rachel Bilson | Guest Star | ||
| John C. Reilly | Guest Star | ||
| Dionne Warwick | Guest Star | ||
| Lori Loughlin | Guest Star | ||
| Warren Beatty | Guest Star | ||
| Peter Gallagher | Guest Star | ||
| Jo Anne Worley | Guest Star | ||
| Melinda Clarke | Guest Star | ||
| Michael Nielsen | Guest Star | ||
| Caroline Rhea | Guest Star | ||
| Marcia Cross | Guest Star | ||
| Matthew Lahey | Director |