The year is 2021 and the world is in a state of chaos and fear. The ancient OOO has come back to life after 800 years of sleep. The ancient OOO has also resurrected the Greeeds, Uva, Kazari, Mezool and Gamel, who want to exterminate humanity and take over the world.
Shintaro Goto and Akira Date, who once fought the Greeed, fight back as the resistance. Hina Izumi, Chiyoko Shiraishi and others support them. And Eiji Hino, who had gone on a trip, returned.