The gang run afoul of a modern-day descendant of Captain Nemo while on their way to a musical gig on Pago Pago Island. Loosely based on "Twenty Thousand Leagues Under the Sea."
Thanks to Alexandra's scheming, the gang, thinking that they are headed to Nashville for a gig, end up in the Amazon rainforest, where they encounter an evil botanist named Dr. Greenthumb, his man-eating plants, and a tribe of headhunters.
While in Bombay, the gang mistakenly enters the lair of a sinister organization called the Secret Six, which plans to replace an Indian leader with one of their number with the use of a potion that can manipulate a person's facial structure.
Valerie bears an uncanny resemblance to an abducted Arabian princess and thus becomes involved in a plan to catch her kidnapper, a hypnotist known as the Evil Eye.
While skiing in the Alps, the gang ends up in the clutches of a baron calling himself Dr. Midas, who plans to destroy the world's entire supply of gold unless half of it is given to him.
During a trip to England, the gang meets Professor Isaac Belfour who has created an invisibility potion. Professor Belfour's former lab assistant, who stole the potion and used it on himself to embark on a life of crime, now calls himself Mr. X and is intent on stopping Professor Belfour from developing an antidote to the potion. Loosely based on "The Invisible Man."
While in Mexico, nuclear capsules are slipped into Melody's bass drum during a fuel stop. When the henchmen for a power-mad nuclear engineer called the Scorpion snatch the drum, the gang rush to recover the instrument and become entangled in the Scorpion's scheme to rule the world with his weather control device.
Melody innocently buys new shoes in Holland unaware that they contain a message for a spy sent to stop the faceless Master Mind, a master of disguise. Contrary to her usual comic relief role, Alexandria uses the anti-gravity ray gun to save her friends from the Master Mind. Loosely based on "Mission: Impossible."
The gang's plane, heading for Puerto Rico, makes an emergency landing in a Caribbean jungle inhabited by dinosaurs and bipedal apes, all of which are under the control of a mad scientist named Dr. Madro, who can change humans into animals. Alexander is turned into a chicken and then an ape, while Sebastian the cat is turned into a bulldog! Loosely based on "The Island of Doctor Moreau" and "The Planet of the Apes" movie series
The gang's hot air balloon in Miami is set loose and ends up on the island of Dr. Strangemoon, a mad scientist who plans to launch missiles that will devastate the Earth's atmosphere.
Melody comes into possession of a strange ancient coin during the gang's trip to Hong Kong. The Serpent, a mad toy maker, pursues the gang in order to obtain the coin, which is the key to his plans for the conquest of Asia.
While on a relaxing gig in Hawaii, the gang is pursued by a Zepplin bourne criminal known as the Hawk when confidential information is transferred from a tape recorder to Melody's memory.
While in Paris, the gang is entrusted with a mysterious black box by an agent and are told to protect it from a mysterious criminal called the Shadow. When the Shadow discovers that the gang has the box, he and his henchmen embark on an around-the-world chase to steal it from them in the style of "Around the World in 80 Days" and "The Great Race."
The Pussycats are in New York City for a recording session. A mix-up in the mail brings them plans for a top secret device that can deactivate the world's technology. The Pussycats' sheet music, meanwhile, ends up in the clutches of a mad criminal called the Laser, who is determined to get his hands on the plans that the gang now have. It is up to the gang to hitchhike to the Laser's hideout in the Grand Canyon and foil his plans.
The gang encounters an alien spaceship in Peru led by a ruthless alien named Zor, who forces the gang and the local natives to work in a diamond mine.
It seems that the Pussycats have actually got the big gig when the gang is invited by an eccentric Countess to play a private performance on her secluded Mediterranean island, where they discover too late that the invitation was a ruse to obtain young test subjects for her rapid aging mist. Will our heroes end up collecting Social Security at age 25?
A music video featuring Josie and the Pussycats showcasing the evolution and different genres of music. Aired between breaks on Cartoon Network during the late 90s/early 2000s as part of their Groovies series of music videos, which also reran on Boomerang until 2014.
Stan Lee, Scott Shaw, Paul Dini and others discuss the influence that the work of Dan DeCarlo, creator of Josie and the Pussycats, has had on the animation industry.