The new government army centred around Saigo enters Edo. Calling themselves ‘Shogitai’, the old government army (retainers of the shogun) that had served the Tokugawa family assemble at Ueno to wait for an opportunity to rise in revolt. Even though Kyotaro has been recommended by Katsu to study in France at a time like this, he agonises over his role in setting in motion Ryoma’s assassination and the path he should continue to take as a vassal of the shogun.
Meanwhile, Jin, whose condition has been deteriorating, is asked by Matsumoto to instruct the Institute of Western Medicine at a time when Edo is under a full-scale assault. Aware of the time he has left, Jin tries to pass on his entire medical knowledge to the doctors at Jinyudo.
Then the next day finally comes. Kyotaro, who has heard that the new government army will launch an offensive against the old government army, makes a decision. Learning about this, Jin, Saki and the rest …
体調が悪化するばかりの南方仁（大沢たかお）は、松本良順（奥田達士）から江戸が総攻撃にあった際の医学所への指図を頼まれる。仁は、自らに残された時間を意識し、持っている医学の知識を残さず「仁友堂」の医師たちに引き継ごうとしていた。
以西鄉隆盛為中心的新政府軍，進入了江戶；侍奉德川家的舊政府軍，則集結於上野，伺機而動。就在此時，勝海舟推薦橘恭太郎去法國留學，恭太郎為自己今後該走的路，感到十分煩惱。
另一方面，南方仁因為健康每況愈下，拼命想將自己所有的醫學知識，全都教給「仁友堂」的醫師們...
