Lea Thompson plays an ex-government agent, now a wife and mother. She is re-drafted by her ex-beau, played by Joe Penny, to help on a strange case. Thompson's work now is devising puzzles, and the government has a beauty. How can a man riding in a plane knock out the pilot, have the plane dip under the radar, and disappear from the plane in ten seconds?
Prosecutor Phil Rafelson's wife Caroline goes into the hospital for plastic surgery. When the bandages come off, it's not his wife, but a teenage girl who takes off. His wife has been kidnapped by a drug dealer who wants the charges dropped. Frank Darnell (Joe Penny) calls in housewife Kathy Davis (Lea Thompson).
After two CSA agents assassinate their mentors but don't remember the crimes, master puzzle-solver Cathy Davis, a.k.a. Jane Doe, connects the incidents to a secret government experiment in mind control. Now, Cathy must quickly uncover who is behind this murderous mission -- before the next agent kills.