Three families dealing with difference at Birmingham Children's Hospital, including 17-year-old Tijana, who was born with eyes that are unusually small and has reduced vision. First-time parents Charlotte and Dan have just had baby Lily, who was born with a cleft lip and palate, and against their protective instincts, they are putting her forward for corrective surgery at just six weeks old. Meanwhile, rock fan 14-year-old Ellie and her dad Gary bring their own unique energy to the Emergency Department, but Ellie's mood is volatile as she battles feelings of depression.