The story of three generations of daughters-in-law who have lived in a 300-year-old traditional house. Choi Mak Nyeo is the daughter-in-law of the 11th generation. She may be small of stature, stubborn and recalcitrant, but she has lead the large household with dignity and her powerful charisma ever since her husband died.
Cha Hye Ja is the daughter-in-law of the 12th generation. She lost her husband in an accident when she was young, and since then she has been dedicated to her role as a daughter-in-law of the family, taking care of the family with warmth. One day, however, her lover from the past suddenly shows up, and Hye Ja is thrown into a quandary.
Oh Young Shim is the 13th generation daughter-in-law, adored by everyone for her bright personality and optimism. Unfortunately, her lack of children even after 10 years of marriage makes her increasingly guilty. The situation worsens when her husband has an affair and demands a divorce, but is killed in a sudden traffic accident.
氏家族滿月堂，是具有三百年悠久家族歷史，經過韓國政府認證的傳統宗族大家庭。家族的長孫媳-吳英心（辛愛羅飾），與家族奶奶、婆婆以及一群妯娌金琴實（林藝真飾）、金妍靜（李荷妮飾）、金順靜（金俊馨飾）一同維繫這個宗族的傳統。在這個大家庭中，有著一個共同的遺憾；就是這個家族的男人都不長命！尤其是長孫金洪玖（尹多勳飾）與英心結婚十年沒有生下一兒半女，就因為車禍意外身亡，另外一個孫子在事業失敗後，也拋棄妻子韓慧媛（姜京憲飾），帶著小三逃到國外，眼見滿月堂三百年的悠久香火竟然就要斷送於此，讓家族奶奶崔末女（姜富子飾）與婆婆車順子（金甫娟飾）不勝欷噓，更心急如焚。雪上加霜的是，兩個孫媳婦-英心與慧媛，在失去丈夫後，分別愛上了知名財團「Queens」集團的兩個兒子文信宇（朴胤載飾）、文振宇（李勳飾），連守寡多年的婆婆車順子，也在遇到兒時的青梅竹馬張錫南（李瑩河飾）後，動了凡心。愛情來了，銅牆鐵壁都擋不住，更何況是滿月堂殘舊頹敗的矮牆？滿月堂的女人們，究竟應該守著這座三百年的大宅院終老一生？還是應該勇於追求屬於自己的幸福？
