"Cocaine Express" is a short documentary about the experiences of photographer Henry Herr Gill and writer Rick Soll, journalists for the Chicago Sun Times. They describe the details and enormous scale of the underground drug trade between the United States and nations in South America. The footage is mostly black and white photographic stills with Gill and Soll narrating. They trace their steps through different South and Central American towns, and talk about various characters and situations they encountered along the way.