Ten new reality TV villains compete for the title of America's Ultimate Supervillain and a $200,000 cash prize; the first battle royale gives a villain immunity, and the first three villains are nominated for elimination.
| Name | Type | Role | |
|---|---|---|---|
| Joel McHale | Host | ||
| Safaree "SB" Samuels | Actor | Himself | |
| Jessie Godderz | Actor | Himself | |
| Richard Hatch | Actor | Himself | |
| Teresa Giudice | Actor | Herself | |
| Victoria Larson | Actor | Herself | |
| Kandy Muse | Actor | Herself | |
| Larissa Lima | Actor | Herself | |
| Tiffany Pollard | Actor | Herself | |
| Wes Bergmann | Actor | Himself | |
| Camilla Poindexter | Actor | Herself |