From Mila Kunis, to Ed Sheeran, to Steve-O, Da Bomb Beyond Insanity had its way with Hot Ones guests all year long—not to mention Sean Evans, from time to time. Take a look back at some of 2021's best reactions to the infamous #8 sauce in the Hot Ones lineup—including Paris Hilton’s at-home meltdown and Jack Harlow’s epic struggle.