From 1850 until his death in 1890, Sitting Bull symbolized the conflict between settlers and native American culture over lifestyles, land, and resources. Sitting Bull led the Sioux resistance against U.S. incursion into Indian lands, resistance that often ended in battle. After the most famous battle at Little Big Horn, in which General George Custer's forces were completely annihilated, Sitting Bull left the United States for the Cypress Hills in Saskatchewan.