The film examines the life and career of photographer and activist Nan Goldin and her efforts to hold Purdue Pharma, owned by the Sackler family, accountable for the opioid epidemic. Goldin, a well known photographer whose work often documented the LGBT subcultures and the HIV/AIDS crisis, founded the advocacy group P.A.I.N. (Prescription Addiction Intervention Now) in 2017 after her addiction to Oxycontin, and near fatal overdose of fentanyl. P.A.I.N. specifically targets museums and other arts institutions to hold the art community accountable for its collaboration with the Sackler family and its well publicized financial support of the arts. Since P.A.I.N.'s activities most of the targeted museums have severed all ties with the Sackler family and in 2021 Purdue Pharma filed for bankruptcy.