Something is rotten in Chillicothe, Ohio. In just 13 months six women have gone missing, four have turned up dead. Filmmaker Joe Berlinger and Intelligence Analyst Angela Clemente team up to figure out what happened to them.
As three more women disappear, the town becomes fearful of a serial killer; Joe and Angela enlist the help of criminal profiler Steve Bongardt; after the capture and conviction of one possible murderer, some remain unsure they found the real killer.
The opioid epidemic rages as the town sends out a SWAT team to bust the dealers; a jailhouse informant reveals new persons of interest; a phone with a shocking message mysteriously disappears at the police station.
Tracking Dollar Bill's ruthless drug empire leads investigators to Columbus where they find two more missing women and evidence of a brutal sex trafficking trade.
Investigators track Dollar Bill to Portsmouth, N.H., ground zero for a deadly heroin epidemic; another missing woman leaves behind a shocking trail of clues exposing police informants in a deadly game of cat and mouse.
As Dollar Bill seems to be informing on fellow dealers in a federal drug case, his associates start coming forward with critical information; the FBI searches Dollar Bill's former trap house for a victim's burned remains.
Investigators meet with law enforcement to facilitate a search warrant for a possible murder victim's burned remains while staying suspicious of their motives; a new suspect with a history of violence against women emerges.
In the series finale, investigators reveal what they have uncovered to the victim’s families. The next generation is inspirational in battling the heroin epidemic. It is determined whether Dollar Bill is to be held accountable for his crimes.