Once again, G.I. Joe must protect the world from global domination. Golobulus, the deadliest of enemies and leader of an underground race of snake people, is proving to be a great threat to humankind. After spending many generations underground, he plans to take over the world again with the help of his henchmen Pythona and Serpentor by releasing deadly spores into the atmosphere. These spores can transform mankind into the weakest of creatures, which means humans could potentially devolve into amoebas. However, in order to accomplish this, Golobulus must acquire the Broadcast Energy Transmitter. Fortunately, the G.I. Joe action force is there to stop Golobulus and his evil army.