Extreme Bodies profiles conjoined twins Lori and George Schappell who are joined at the skull and partially share a brain. Scientists use MRI machines to determine that they do not share thoughts. It then examines the case of Krista and Tatiana Hogan who are joined at the head, but also seems to share a mental activity. Finally, the surgery examines the delicate operation to separate infants Erin and Jade Buckles who are conjoined at the chest.
Extreme Bodies examines how human bodies are straining now that food is plentiful. It examines the case of Manny Yarborough a retired sumo wrestler who has packed on a large amount weight since retiring. The strains on Manny's body are examined with computer graphics and 3-D imaging.
Extreme Bodies looks at human giants and examines how genetic variation and sometimes small tumors cause people to grow significantly in height. It looks at the case of George Bell who is the tallest man in the United States and uses MRI scans and computer 3-D imagining to examine his body. It also looks at the case of Dave Rasmussen a giant whose height results from a genetic mutation. It also talks to basketball player Roy Hibbert and former basketball player Richmond Edwards.
Extreme Bodies looks at dwarfs and examines how certain genetic conditions can result in people who are much smaller in height than average. Ir uses MRIs and computer to take a look at how dwarfism can affect bone growth and interviews several athletes who compete at high levels despite their dwarfism. It looks at several different conditions including hypochondroplasia, achondroplasia, and primordial dwarfism. It also examines the controversial practice of limb lengthening.