In an apocalyptic world, two brother's Gabe and Rafe are protectors of their town. The mayors daughter runs away with a bunch of Amazonian giant mutant women and the brothers go rescue her. While this happens Judith, the brothers mother, stuck in a super bunker called AENUS attempts to escape through the vents.
A rocker mutant named Manson and his roadies take over the town and cause havoc for everyone. Judith attempts another escape by re-wiring AENUS only to set destroying security drones on herself.
Chudley, Rafe's mutated dog changes bodies with Gabe. Mayor Dwayne enjoys getting Hallucinations on Johnny's tears. Judith finds a classified filing cabinet with classified military secrets but finds someone by the name of Johndoe Coprety who she finds survived the explosion.
Gabe and Rafe are recruited by the Giant mutant amazonian girls to get it on with their giant (even bigger) queen but screw it up and get help from Johndoe Property. AENUS has a problem and is running low on power, but Judith won't fix him unless he sends a message to her boys. When she gets what she wants AENUS allows it and sends a message. This fails and AENUS runs out of power. At first, Judith does nothing until she has a change of heart and fixes AENUS.
Gabe is discovered making out with a female limbless mannequin, while Rafe is celebrated for killing a one-eyed mutant peeping tom on Suzette. Gabe drives away to a bunker he grew up in with his mother to escape humiliation from Rafe's celebration with the mannequin but finds out Rafe escaped himself in the vehicle. They both soon get chased by Manson to the bunker and later escaped leaving the mannequin behind, Gabe finds out that Rafe was not telling the truth about the mutant. Judith replaces AENUS with a 1960s AI only to find that its 60's programming won't allow her out of the super bunker. A false preacher enters the town to cause trouble with the town folk and only Vijay and Father Mannilla can save them.
Gabe and Rafe play poker with Johndoe for a pile of batteries and in the end win, but they also win a mutated slave under the preferred term Intern. During the day the two brothers use him and even allow Dwayne and Suzette to borrow him. Seeing the two abuse him, the brothers see what they become and try to tell the intern he is free but the intern stays and willing offers his loyalty. Gabe forces the intern to leave but Manson makes his appearance soon after and orders his intern back. To repair the damage caused by Johndoe the brothers become interns for Manson and he decides to sell them. In the end, the mutated Intern buys the brothers. In the super bunker, Judith hatches a plan to fake her death to trick AENUS to shoot her out of the bunker trash shoot. As usual, the plan fails as AENUS explains any trash that's thrown out gets sent to be incinerated. Close call for Judith.
After the citizens discovered Anna was making secret biological notes on everyone because of their mutations. They shun and banish her from the town. Anna does not mind in the lest and leaves. She meets a large talking mutated mouse with a third large human ear on his back in the wasteland and soon they become intellectual friends with common interests. Later things change and Anna sees his true colours, she manages to get the mouse to town and subdues him to study him since her curiosity about biological animals was greater. This scares the citizens and they make up with Anna. In the super bunker, it's Judith's birthday AENUS decides to give her a present. The present is a helmet simulation of her escaping out of the bunker. This soon becomes a prank than a present as each time Judith finds herself each time taking off the simulated helmet.
Gabe saves a mutated female stripper praying mantis and she decides to become her lover. She takes advantage of her stay and gives birth to a magot mutated toothed baby which decides to instinctively eat the trapped Rafe, Anna and Dwayne. It is up to Gabe between his new lover and his friends. AENUS is having trouble sleeping and Judith helps to escape the super bunker. During their talk, AENUS talks about his mother. As usual, AENUS sees through her plan. Danika interrupts Vijay's love with an invisible girl, only to accidentally murdering the invisible girl's invisible boyfriend and burying the body. Vijay tells Danika he was dumped by his new girlfriend and in the end the two walk home with three unhappy invisible parents and a former invisible girlfriend.
Rafe has an identity crisis when he suddenly sprouts breasts, but his new endowments might just save the town from a painful flu.
Rafe and Gabe find a cave that can clone people based on thoughts and memories and they each “clone” an ideal version of their mom, but the two Judiths quickly go to war.
Rafe and Gabe sign up for a gladiator competition to win supplies, and Gabe’s anxiety becomes their secret weapon.
Rafe discovers that his attractive fish-mutant girlfriend wants him to replace her lackluster husband.
When Rafe gets a parasite that convinces him he’s a prophet speaking God’s words, the town follows Rafe on an exodus to find an oasis.
After Suzette becomes mayor of St. Zephyr, the town is infested with sandwich-sprouting vines that make everyone paranoid and hostile.
After offending all of the town’s mutants with his jokes, Rafe accidentally gets transformed into a hideous mutant.
After a fight with Rafe, Gabe falls under the influence of shadowy General Hecks.
After a night of drinking, Dwayne and Suzette awaken on a mattress in the middle of main street, chained together at the ankles with no memory of what happened.
General Hecks gets into the Super Bunker and it’s up to Rafe and Gabe to stop him from killing their mom.