The team, tired of being stuck in Doom Manor, decides to visit the local town while The Chief is away. However, this seemingly harmless field trip leads to some grave consequences, including an encounter with the mysterious and powerful Mr. Nobody.
Following Mr. Nobody’s capture of Niles Caulder and the destruction of Cloverton, Ohio, The Doom Patrol investigate the mysterious albino donkey and discover it is a door to another universe, one where Mr. Nobody is in control. Cyborg aka Vic Stone, a part man/part machine hero from Detroit who has his own complicated relationship with Niles Caulder, joins the search.
Following the only lead in the search for Niles Caulder, the Doom Patrol sets out for Paraguay and discovers Dr. Von Fuchs, the Nazi doctor who transformed Eric Morden into Mr. Nobody, and learns the connection between Niles and the two villains.
As the team recovers from the fight at Fuchtopia, Willoughby Kipling, an old friend of Niles', unexpectedly conscripts the Doom Patrol into helping him avert the end of the world by stopping a cult, but the team fails and the apocalypse begins.
With the Apocalypse in full swing, the Doom Patrol must work with an unlikely ally and a very special pug to stop the end of the world.
Following a clue left by Mr. Nobody, Jane, Larry and Rita visit a school where Niles' previous team of heroes, the original Doom Patrol has retired; Cliff and Vic tenuously bond over their mutual "father issues."
After a violent outburst from Cliff, the team engages in some self-led group therapy, leading to some growth within the group as they are knit closer together.
Danny, a sentient, gender-queer, teleporting street who is being hunted by secret government agency the Bureau of Normalcy, needs help from Niles but he gets Vic and Larry instead. Cliff and Rita track down Karen, one of Jane's personalities.
Jane retreats into The Underground, a treacherous place deep within her own mindspace, where she encounters her many personas and dark traumas of her past.
Vic and Rita find the mansion infiltrated by Ernest Franklin, a dangerous man called the Beard Hunter, who has been activated by the Bureau of Normalcy to find Niles Caulder, the tragic love story that started Niles on the path toward the man he is.
While Larry pays a visit to his lost love, John, both in real life and in the Dreamscape. Cliff travels with Rita down to Gator Country to reconnect with his daughter after 30 years; Jane and Vic pursue the "Hero of the Beach."
With Vic captured by the Bureau of Normalcy and held at the Ant Farm, his father, Silas Stone, hatches a plan to break him out with the rest of the Doom Patrol, but everything doesn't go according to plan.
After escaping the Ant Farm with Flex Mentallo, the Doom Patrol tries to restore his memory and abilities in order to find the Chief; Rita confronts her doubts with the help of a stranger, and Larry realizes how tied he is to the Negative Spirit.
The Doom Patrol finally lands on the threshold of rescuing the Chief from the clutches of Mr. Nobody. With help from Flex Mentallo and Danny the Street, the group enters the White Space, where Mr. Nobody offers a chance to start again.
In the wake of the Chief's revelation, the members of the Doom Patrol go their separate ways. When Mr. Nobody hatches a new plan, the team must reunite to help the Chief with a new, unexpected and weird threat to the world.
The Doom Patrol (along with Niles & his daughter) are still mini-sized after their last adventure. Ultimately, Niles will have to sacrifice something precious to save the team.
Cliff, Jane, and Rita pursue a time-altering doctor in their reluctant quest to help Niles and Dorothy. Meanwhile, Vic meets a military vet who challenges his beliefs.
Niles, Rita, and Larry end up in the interdimensional clutches of Red Jack, an infamous villain who feeds on pain, while Cliff visits his daughter with Jane.
When the Dannyzens throw a massive party at Doom Manor to resuscitate Danny the Brick, Dorothy longs to join the festivities and experience life as a grown-up. As the party rages on, Rita asks Flex Mentallo to help unleash her full potential -- which has some dangerously racy consequences.
Dorothy finds a friend in Baby Doll, while Vic looks to win Roni back. With Rita’s help, Larry finally tries to break the ice with his family.
As Niles and Cliff set out to find a missing Dorothy, Larry is tasked with handling Niles’ old research team when the ageless aeronauts return from space.
While Niles heads north to find Dorothy’s mother, the Doom Patrol embraces their inner morons after receiving a mysterious package.
While Jane sets out to prove her worth in The Underground, Cliff goes into “dad” mode and Niles devotes a day to Dorothy, who’s finally growing up.
Before the Doom Patrol can answer a call to save the world from The Candlemaker in the season finale, they must first battle long-forgotten imaginary friends.
Dorothy and the Candlemaker finally face-off, while the Doom Patrol – now freed from their wax encasings – face troubling side effects. Rita holds the key, but is she ready to answer the call?
A relaxing vacation to escape the Doom Patrol’s recent loss proves anything but – especially when an unexpected evil lurks nearby.
After waking up in the tunnel of souls, the Doom Patrol must confront their own personal purgatories. Back at the manor, Dorothy and Larry consult a highly specialized detective agency to help reach their friends.
The newly “undead” members of the Doom Patrol are inspired to work on themselves. Later, the team is rocked by the arrival of a mysterious woman on a time machine – and a former foe.
Madame Rouge enlists the Doom Patrol’s help after learning about her unsettling past. While the rest of the team works to infiltrate the target, Rita stays behind and finds a surprising connection with their mysterious friend.
Plunged back in time, Rita attempts to navigate the Bureau of Normalcy with help from an oddly familiar group. Meanwhile, Jane gives Kay her first taste of freedom, while Larry finds closure with his son.
Vic consults an old friend for help with a major life change, Cliff takes his online habits too far, and Jane battles the “others” for Kay. Sensing imminent danger, Madame Rouge attempts to rally the highly distracted group.
While the fog obscures more than just the air, Vic, Cliff, Jane, and Larry must relive their most shameful moments until a breakthrough occurs, and Rita begins to better understand Madame Rouge.
With Madame Rouge vying for her old spot in the Brotherhood of Evil, the Doom Patrol brace themselves for their impending visit.
As the Brotherhood of Evil closes in, the Doom Patrol try to set aside past issues in hopes of becoming a true superhero team – or risk being taken out for good.
As they struggle to function as a cohesive group, the Doom Patrol are confronted by a horrifying realization in the future.
A desperate Doom Patrol strategize ways to wipe out the zombie butts… and reverse their grim future.
Larry and Jane seek new purpose in Keeg and Kay’s absence. Vic attempts to reconnect with his old crew. A mysterious invitation to a retrospective comes at the perfect time for a newly ousted Rita.
When the safety of Danny and everyone housed within is compromised, Dorothy is forced to step up with some unexpected help.
When Rita awakens unexpectedly aged, a mishandled spell teenage-ifies the Doom Patrol just as Willoughby asks for their help stopping the rise of Immortus and the end of the world as they know it.
With the end of existence imminent, a determined Doom Patrol seek to get their longevities back and save the universe.
As Jane ropes Cliff into longevity-hunting, Vic and Deric search for Larry, and Rouge tries to sway Rita into joining her on a trip to Orqwith.
As Dorothy and Casey team up for a new mission, the Doom Patrol's pursuit of Immortus leads them to a superhero parade.
A music-filled Immortimas Day forces the Doom Patrol to reckon with the people they've become -- and who they once were.
After believing she's uncovered the source of Immortus' power, Rouge tries to convince the Doom Patrol to help excise it.
Thrown into a time stream, the Doom Patrol have just one hour to find their longevities, rescue Rita and save the world.
After returning to Cloverton, the Doom Patrol gather for a final mission -- one that proves to be unlike any they've had before.
