Det er igen tid til at møde nogle helt unikke børn. Nogle kender vi, og andre er nye. Fælles for dem alle er, at de kæmper for at få det bedste ud af livet på trods af deres sjældne sygdom. Piet er tilbage, og sammen med vennen Hjalte sætter de nye standarder for at være fodboldfans. Mød også den charmerende Nalina på fire år, som lider af Sticklers syndrom. Hun skal være storesøster, og spørgsmålet er, om lillebror også risikerer at få den arvelige sygdom - og det sætter forældrene i et dilemma. Rebekka på 13 har Morquio syndrom og kæmper med udsigten til et teenageliv uden at kunne det samme som sine jævnaldrende veninder.
It's time again to meet some very unique children. Some we know and others are new. What they all have in common is that they fight to get the best out of life despite their rare disease. Piet is back, and together with his friend Hjalte, they set new standards for being football fans. Also meet the charming four-year-old Nalina, who suffers from Stickler syndrome. She is to be an older sister, and the question is whether the younger brother is also at risk of getting the hereditary disease - and this puts the parents in a dilemma. Rebekka, 13, has Morquio syndrome and struggles with the prospect of a teenage life without being able to do the same as her peers.
