George Washington sends Daniel and Yadkin into ""Ken-Tuck-E,"" the ""dark and bloody"" hunting ground of four Indian nations, to find a site for a fort. Once they arrive, they encounter representatives of two of those four nations -- Shawnee warriors chasing a lone Cherokee warrior. Daniel helps drive the Shawnee away, and the grateful Cherokee, Mingo, returns the favor by showing Daniel and Yad an ideal location to build their fort. Yad returns east while Daniel remains with Mingo to explore the country.
A man called Flathead Joseph kidnaps the adopted daughter of a Cherokee chief and offers her to the Boonesborough settlers in exchange for a jug of rum. When it's revealed that the girl is in reality white, Daniel purchases her freedom. Then the Cherokee arrive on the scene and want to take the girl back to live with them. Some of the settlers do not agree that she should return but the girl herself wants to go
Israel accidentally startles a passing peddler's horse and his goods are ruined. Daniel agrees to compensate Seth Jannings for his loss, but matters are complicated when Jannings steals a sacred mourning doll from the wife of a Native American chief and plans to hold it for ransom. Knowing that this could lead to major hostilities with the Native Americans, Daniel puts his own neck on the line to retrieve the doll from Jannings.
Daniel Strikes out alone to find and capture Rawls (Rafer Johnson), a powerful runaway slave, who steals fur pelts by night to earn his passage back to Africa. The Renegades who've hired Rawls to steal also want him back so they can turn him in and collect the bounty. They kidnap Jemima Boone (Veronica Cartwright) to force Daniel to make a trade.
Little Israel Boone rescues an aged half-starved Indian Nitashanta, from death in a dark cave only to discover that he has violated a centuries old burial custom.
Boone develops a mutual respect for and bonds with a notorious renegade, John Benton, as they fight untold odds together on the lengthy trek to Benton's hanging.
Daniel and Mingo find themselves party to a mysterious figure from the long-dead Aztec nation on a journey to the Shawnee's forbidden Valley of the Death.
Boonesborough's chances to win the annual Spring Foot Race with the Indians hangs in the balance when Boone, the fort's best runner sprains his ankle prior to the hotly contested race. Robert Logan as Jericho Jones becomes a regular cast member in the is episode.
Enemy Chickasaws help Boone save Kentucky and its settlers from the greed of a fanatic British officer who means to seize the rich country for himself and sell its dwellers into bondage.
Israel Boone, Cherokee chief Menewa's son Monlutha and Dougal, so of Scottish settle Roderick MacIntosh work to gather to help prevent war between the settlers and Indians by preparing peace medicine.
Boone's eccentric father-in-law (John McIntire) concocts a Thanksgiving Day plan to prevent a Choctaw attack.
Disgraced Vice President Aaron Burr arrives in Boonesborough looking for a guide to the mouth of the Cumberland River. Daniel smells a rat and declines but young Jericho Jones agrees to undertake the task.
Feelings for Jemima make a dashing young outlaw (Fabian) consider reforming.
Two scumbag land developers hire English boxing champion Thomas Cromwell to dispose of Daniel in a prizefight so they can buy up Boonesborough property.
On a cold Christmas Eve, hungry Boonesborough awaits the birth of an Indian child who could reconcile two tribes.
Vigilantes stalk Mingo after his knife falls into the hands of a Cherokee who murders a trader s family.
Daniel and Rebecca finally get to take a long delayed honeymoon but it gets interrupted by an officer of the Continental Army with a confidential message for Daniel to deliver to New Orleans.
The sister of a British officer lies that she narrowly escaped an Indian massacre; Boone must avert war.
A Spanish military expedition chasing a French revolutionary mistakes Boone for its quarry; guests Cesar Romero, Mike Mazurki.
A bounty hunter seeking Army deserters learns one of his captives is valuable Boone.
A former Continental Army officer (George Sanders) uses a smallpox threat to raise troops against Indians.
After Seminoles hail him a god, a magician lets his power go to his head; guests Diane Ladd, Leonard Nimoy.
Boone heads to Pennsylvania to have a new gun made, but meets two scoundrels seeking a guide to the Mississippi.
Three escaped Army prisoners, seeking revenge on a former commander, pressure Boone by seizing his children.
Boone and his party endure hardship to blow up a bridge between the advancing British and Fort Wayne.
Daniel tries to avert bloodshed between the Shawnee and road builders who have started building through tribal hunting grounds in direct violation of a treaty.
An ambush on the way to New Orleans leaves Boone in possession of a famous pirate s journal.
Cashiered British Army officer William Blount steals a shipment of 50 rifles and plans to trade them to the hostile Shawnee in return for a tract of land.
Renegades take Israel hostage when they find him and injured Mingo in the forest; guest Lloyd Bochner.
Mingo arranges a prison break to free Boone after a couple frames him for murder; guest Joanna Moore.
A man (Royal Dano) finds only danger when he seeks a fabled city of gold; guest Alejandro Rey.
This two-part episode deals with the early years of Daniel Boone's life and how he met both Rebecca and Mingo. It also re-writes things a bit from the show's premiere episode as to how he first settled in Kentucky and first encountered the Oxford educated Cherokee.