The BAU team travels to San Francisco to investigate the murders of several homeless men and teams up with a separate group of BAU operatives who are working another case they think is connected.
After a spree killer targets three Oklahoma City residents with the same physical description, Cooper and the Red Cell team are called to uncover their connection before the situation escalates.
The Red Cell team must track down a suspect who is kidnapping young mothers. Meanwhile, Beth discovers why this particular case hits close to home for Mick.
Cooper is called to testify when a case involving a woman on death row petitions for a mistrial based on the testimony given by FBI director Fickler. Meanwhile, Cooper puts Beth in charge of threat analysis.
Cooper and the red cell team track a serial killer who is randomly shooting people in crowded areas. Also, Beth's life is put in peril when she and Prophet go undercover.