In order to help contain the spread of Covid-19, each member of the public needs to be best prepared for the weeks and months ahead. However, the reality of self-isolation can be difficult, while the advice is complex and changing all the time. Here, Dr. Xand van Tulleken and psychologist Kimberley Wilson offer a no-nonsense guide to self-isolation, full of useful tips and advice to help people to self-isolate successfully.