In 2016, we will see the continuation of conflicts and rivalries in the Middle East. More countries will get entangled in the Syrian Civil War, but we will also see a reemerging Turkey. The Saudi-Iranian rivalry will reach new heights and Israel will have to rethink its geopolitical position. Further North in Russia, the low oil prices will force Moscow to push hard for economic reforms. Financial changes will also occur in Europe, where many nations will struggle with their economies, which in turn will inspire the rise of nationalism. However, there are also exceptions such as Switzerland, where are important referendum could trigger a financial revolution. In this prognosis, we will go over the most likely diplomatic, economic and military outcomes for Europe, the Middle East and Central Asia in 2016. In Part 2, the prognosis will continue in East Asia, Africa, and the Americas.