Headaches are often a chronic and disabling condition, and among migraine sufferers alone, cause 157 million workdays in lost productivity. Fortunately, we are closer than ever to fully understanding the causes of this biological disease. We meet an artist whose migraines have been the inspiration for his award-winning art. We discover that the ancients drilled holes in the skulls of headache sufferers. And finally, we learn about some of the latest scientific research into migraines and investigate biofeedback to reduce tension headaches.