Christine is surprised to discover that the driver of a vehicle involved in a serious road traffic accident is none other than her husband, Kenny. David's first day at Saint Victor's goes from bad to worse when he is assaulted by a patient with mental difficulties. Louise is forced to make the tough decision to withdraw care to an elderly patient who is unable to breathe on his own. Stuart's ongoing dispute with his neighbors ends in disaster, and Mike's children try to encourage him to expand his social life.
Mike deals with a suicidal man who refuses treatment that could potentially save his life, but Cathy sees it as the perfect opportunity for Mike to ask hospital psychiatrist Susan out on a date. Louise inadvertently puts a youngster at risk after misdiagnosing his condition as glandular fever, but Robert manages to use the situation to avoid Issy's latest scan. Christine continues to probe Kenny for information about his relationship with Mary. David has an interesting day dealing with a number of minor injuries.
Robert battles to save the life of two road accident victims, one of whom is pregnant. Mike is grilled over his choice to continue treating a suicidal man who initially refused to be treated. Christine treats an accompanied prisoner complaining of strange symptoms, and discovers that his presence at the hospital is simply a ploy to allow his girlfriend to visit. Stuart's sister-in-law is admitted after a suspected mugging, but he begins to suspect that his brother could be subjecting her to a campaign of domestic violence.
Stuart is shaken when a brain hemorrhage patient he is treating suddenly deteriorates, after informing her parents that she is in recovery - but when he informs a heart transplant patient that the girl was carrying an organ card, Mike is forced to question his judgement. Louise's medical capabilities are called into question after orthopedics make a complaint to Robert about the number of unnecessary referrals she is making, but when David tries to intervene and play the hero, his efforts are swiftly rebuffed.
With Robert away for the night, Mike is left in charge. When a local football team are admitted following a road accident, the team are rewarded with a free takeaway as a way of saying thank you. However, the celebration quickly turns sour when the takeaway provides an outbreak of food poisoning. David and Yvonne are left to run the department single handed, and David uses the opportunity to prove himself. But when one of his former mentors is admitted as a result of a heroin overdose, his loyalties are tested.
When two gunshot victims are left outside A&E, Stuart is forced to leap into action, but despite Robert's best efforts, one of the victims dies of his injuries. Cathy and Louise deal with the father of a young girl who is killed in a road traffic accident. Stuart's brother decides to leave his wife and go on the run. David tries to advance his fledgling relationship with Yvonne. When Cathy tenders her resignation, Mike finally gets around to asking her out on a date. Christine decides to finally pluck up the courage to leave Kenny.
Christine's professional judgement is put to the test when a man with severe burns rejects urgent treatment. Stuart deals with a group of schoolchildren involved in a minibus accident, but inadvertently faces the wrath of one angry parent. Robert returns to A&E to show off newborn baby Harry, but ends up getting roped into dealing with two window cleaners involved in a serious accident. David continues to try to win Yvonne's affections, and Christine has a new admirer in the form of new pediatric doctor Andrew Argyle.
A young female who arrives in the department complaining of abdominal pain is discovered to be pregnant, and with contractions well underway, Robert faces no choice but to deliver the baby himself. Terry consoles a young woman who is admitted after cutting her wrists. The department is thrown into turmoil when a patient is admitted covered in a mystery powder, forcing Resus to be put into quarantine. Christine receives a call from a friend at City General to inform her that Issy has been involved in a serious accident.
Robert returns to work, but begins to crack under the pressure. Christine deals with a young girl who has been hit by a bus, but denies the police access to the bus driver until she can determine the identity of a mystery substance found in the girl's bloodstream. Mike angers a young mother after accusing her of abusing her six-year-old daughter. A young girl with slash wounds to her wrists is found collapsed in reception, and Stuart takes a leap into the unknown by treating a trauma patient at the scene of a hit and run.
Christine is made acting consultant in Robert's absence. Mike battles to save the life of a drowned child, but the father's attempts to hide the truth surrounding the boy's accident make it harder for him to administer the correct treatment. Stuart and Louise deal with a case of domestic violence involving a severed finger. David's latest attempt to bring the department up to speed with cutting edge technology leaves him with egg on his face, and Mike is shocked by the arrival of an unwelcome visitor: his ex-wife, Stella.
Robert faces his first day back at work after Issy's death, but is confronted with a barrage of sympathy and criticism following his shaky treatment of an asthma patient. David misdiagnoses a woman suffering from abdominal pain, and when she is later found collapsed at home, Robert discovers that she is suffering from an ectopic pregnancy. David's day goes from bad to worse after he tries to make Martin see the error of his ways in spectacular fashion. Cathy finds herself being used as a go-between by Stella.
David is forced to deliver heartbreaking news to regular patient Martin, after an X-ray discovers traces of a rare form of bone cancer. However, after his grilling from Robert, David realizes that it could be make or break for his career in A&E, so decides to pull out all the stops. Stuart is forced to confront his feelings for Mandy after she is assaulted by a drug smuggler. Mike manages to clear the air with Stella, while new doctor Kate Brady surprises Louise with her skillful treatment of patient refusing to see a female doctor.
Robert fears that he has lost his appetite for the job and turns to Christine for help. David is shocked when Martin passes away unexpectedly. Mike arranges for Stella to meet Paul and Richie for the first time in seven years. Kate struggles when faced with a patient who has suffered an ankle fracture in a car accident. Christine informs Andrew that she does not intend to pursue their relationship. Louise tackles a particularly difficult student whilst taking an educational course on the effects of road traffic accidents.
A busy Friday night shift ends in tragedy after two children involved in a car accident die shortly after their arrival at the hospital. The situation is intensified when Cathy discovers that the police officers who were first on the scene have misidentified one of the casualties. Meanwhile, Mike and Stella come head to head over his parenting skills, Robert struggles to juggle with life as a single parent, Andrew offers to help David with a difficult young patient, and Louise and Stuart finally put their cards on the table.
Robert faces the challenge of his career when he leads a team to free the survivors of a horrific air crash. Among those trapped in the plane are a six-week-old baby, a seven-year-old schoolgirl and a businesswoman suffering from an aortic rupture. While he tries to regain his passion for the job, Kate struggles to keep her emotions under control. Judy begins to question her future in A&E, and Andrew's efforts manage to impress Christine. David begins to buckle under the pressure, but manages to impress Robert.
Christine tends to a boy injured a fight, but during examination she discovers injuries that suggest an involvement with child prostitution. Stuart tries to help a young mother whose baby is suffering from severe diarrhea. David makes friends with a local busybody and ends up getting him volunteer work at the hospital. Mike continues to fight Stella for custody of the children. Louise tends to a young girl who has a blocked windpipe, but struggles to keep her mind on the job after discovering that she is pregnant by Stuart.
Stuart tries to prevent a patient showing signs of mental difficulty from being assessed by a psychiatrist, but his day goes from bad to worse when he receives shocking news from Louise. Mike attends court for the first day of the custody battle, but finds himself becoming an unlikely ally for Stella when the pressure of the situation begins to take its toll on Richie. Freddie panics when he learns that he is to be promoted to supervisor. Christine is forced to confront Andrew after a young mother makes a complaint about him.
When a busy night descends into chaos, Robert worries that his department cannot cope. Kate deals with an elderly patient who shows no signs of medical requirement, but is shocked when the woman unexpectedly dies whilst waiting to be transferred onto a ward. Mike tries to persuade Cathy to leave with him for a new life in London. Robert deals with a car crash patient who is impounded on a fence post. Stuart tries to persuade Louise to give their relationship a try, and Terry ends up a fight with a distressed relative.
New nurse practitioner Samantha Docherty's first day goes from bad to worse when a man she met the night before whilst out clubbing is admitted to the hospital in the custody of two police officers. Christine's promotion to consultant, despite being endorsed by Robert, seriously upsets their relationship after she tries to persuade the father of a motorbike crash victim to honor his daughter's wishes by allowing her to be an organ donor. Stuart is shocked to discover that he could not be the father of Louise's baby.
Robert deals with a young schoolteacher who is admitted with a bout of severe vomiting, and discovers that he has inadvertently drunk industrial strength weed killer, making his chances of survival very unlikely. Stuart tries to persuade Louise to move in with him. Jack tries to poach David from A&E to join him in surgery. Samantha refuses to take responsibility for a patient's collapse despite being his allocated practitioner. Robert notices Christine is pulling back from him emotionally and looks to Cathy for comfort.
Louise and Stuart clash over the treatment of a potentially braindead patient, and the stress of the situation forces Christine to question Louise's ability to continue working during her pregnancy. Christine's relationship with Robert deteriorates, and she accuses him of siding with Jack over the dubious diagnosis of a patient admitted after falling from a motorway bridge. Kate receives a harsh warning from Robert after leaving a seriously ill patient to seek help. David plans a party for his last shift in the department.
Jack is appointed clinical director over Robert, and immediately begins trying to get Christine on side. Mike returns from London with the intention of getting his old job back. Robert deals with a twelve-year-old gunshot victim, and tries to persuade her father to tell the police who was responsible. Kate tries to prove herself to Christine whilst dealing with two firefighters injured during a building collapse. Stuart is devastated to discover that Louise is not coming back. Mike is furious when he catches Robert with Cathy.
Robert is outraged when Christine's efforts to stretch the department budget result in a heart attack patient suffering cardiac arrest. Mike deals with a young girl who has an allergic reaction to a tongue stud. Kate is caught moonlighting when a junkie that she treated the previous night turns up at the hospital begging for painkillers. Mike deals with a young woman suffering from abdominal pain, and suspects she may be suffering from an ectopic pregnancy. Christine asserts herself as Robert continues to undermine her.
In an effort to improve departmental relations, Andrew is sent out into the field with paramedics Trish and Brian. When the trio are called to a disused warehouse by an anonymous caller, Andrew becomes suspicious and decides to investigate. He finds a group of twelve illegal Eastern European immigrants trapped beneath a collapsed tower of building cargo, but discovers that the traffickers aren't prepared to let him call for help. As a hostage situation ensues, and Brian is shot, Andrew calls upon Jack for help.
Whilst performing an incubation, Stuart fails to notice that his patient has a recessive jaw, and ends up causing a loss of oxygen to his brain. The aftermath of the situation leads to three-way split between Robert, Jack and Christine as how to deal with the patient's angered relatives. Andrew questions his passion for the job after treating a teenager dancer with a fractured ankle, and Mike is shocked to discover that a fracture patient he has been treating, who shows signs of a possible tumour, is in fact Judy's father.
Robert deals with a gunshot patient who is reluctant to reveal how he received his injuries. The team are angered by a new directive from management which states that only registered consultants are allowed to carry out certain procedures. Stuart, believing his actions are responsible for the directive, is further angered when his treatment of a young rower is interrupted by Jack after he discovers that the boy is the son of a hospital trustee. Judy is devastated when her father unexpectedly dies on the operating table.
Kate and Andrew deal with a mother and daughter who are involved in a serious car accident, but Kate becomes suspicious of the father's reluctance to reveal how he sustained facial burns. The team are pushed to their limits when Yvonne and Cathy are involved in a bad accident whilst out biking. Judy's emotions finally get the better of her whilst dealing with a group of rowdy stag night revelers. Jack and Sam give into temptation following a heart-to-heart. Robert urges Mike to apply for the registrar's post.
Andrew deals with two young children involved in a serious accident on a railway line. Terry has his hands full dealing with a disruptive patient who is determined to bribe her way into theatre. Sam deals with a infected flesh wound involving a lively young couple who have an uncontrollable urge to make love to each other. Mike is angered when Jack sabotages his interview and he loses the registrar's post to Stuart. Sam reveals to Christine that she and Jack slept together. Robert begins to lose his patience with Jack.
Robert is angered to discover that Jack has called a risk management investigator into the hospital to question the team following the incubation disaster. Mike goes head-to-head with Robert over the treatment of a drug addict who appears to be showing signs of sickle cell anaemia, and tries to help a young schoolboy whose problems seem to stem from the lack of attention from his mother. The team use a golden opportunity to prank David when he learns that Zara Phillips is a good friend of one of his patients.
Robert confronts Jack over the risk management investigation. Unwilling to let Robert ruin his mood, Jack attends a hospital fundraiser, but is called away during the festivities by Kate, who is dealing with the victim of a motorbike crash. On his way back, he is involved in a car accident, but having being banned from driving, he flees the scene before the police arrive. Distracted, he makes a tragic misdiagnosis of Kate's patient. Mike deals with a private who appears to have been beaten by members of his squadron.
The arrival of management consultants brings Robert to his lowest ebb, and he is forced to control his emotions whilst dealing with a dementia patient whose daughter is in denial. Terry is pleased to see an old friend, Des, who has been drafted in as agency cover. But when he suspects Des of stealing controlled drugs, their reunion soon turns sour. A coach crash leads to an influx of injured football supporters, and as Christine comes across a copy of the missing X-ray, Robert announces that he is resigning.
Christine confronts Jack and forces him to admit the truth. Robert formally announces that he is leaving the hospital. A gas explosion in a poker club results in an influx of injured victims, and David's inability to thrive under pressure is called into question. Kate deals with the victim of a bicycle crash, and has trouble shaking off a persistent admirer. Christine forces Jack to tell Robert the truth, but Robert isn't willing to sweep the matter under the carpet, and forces Jack to tender his resignation to the board.
A fatal motorway coach crash results in a hectic shift for the team. Danny Barton's first day goes from bad to worse when he inadvertently informs a patient's relatives of their son's death, despite him having been discharged several hours earlier, and then ends up being held at gunpoint by the father of a young boy who was murdered after becoming caught up in a turf war. Jack's capability is called into question when he ignores hospital procedure and performs a brain operation on a dying patient.
Christine is interviewed for the position of clinical director in Robert's absence. Jack discovers that one of his former pupils, James De Costa, is being primed for a new registrar's job in the hospital. Terry deals with two brothers who are injured whilst participating in an illegal fight club. Saskia treats a young woman complaining of abdominal pain, who later reveals that she has taken more than forty pills in an attempt to take her own life. Jack is forced to perform an emergency operation on a pregnant patient.
Robert is surprised to learn about Christine's promotion, but is forced to put his emotions on the back burner to deal with a double stabbing. Christine deals with a difficult patient who has misinformed her partner about her ability to conceive. James tries to perform a tricky procedure on a patient with a dislocated elbow, but Ruth goes above his ahead and contacts Jack. A tense situation arises when Robert is unable to locate blood supplies for his patients. A relative of a deceased patient vows to take revenge on Terry.
An elderly patient admitted with a broken arm makes a live television interview claiming that he was assaulted by a group of black youths. His claims spark racial tension in the black communities of Manchester, sparking a series of incidents which lead to a riot, and Terry and Jay being caught up in the centre of the action. Jay is later admitted after starting a brawl, but unexpectedly comes face to face with a man he attacked. Sam is approached by the leader of a local gang, who claim to be holding her brother captive.
Christine and Ruth come head-to-head over the treatment of a patient involved in a road traffic accident. Poppy's first day as a qualified nurse practitioner goes from bad to worse when she faces a barrage of abuse from a young boy's father. Christine informs the team that Robert has been suspended until the investigation into his outburst is concluded. The gang holding Sam's brother start to put pressure on her, and she makes a shocking discovery about James. Terry struggles to come to terms with Jay's death.
Jack is angered when James takes credit for one of his operations on television. Danny deals with a difficult elderly patient whose daughter suffers from William's Syndrome. Jeffrey tries to push Robert into resigning. Jack is forced to perform an operation on a paraplegic patient without the use of a general anesthetic, and later makes a shock proposal to Christine. James confronts Sam when he discovers that she has been stealing from the drugs trial. Robert and Sunita face up to their feelings for one another.
Danny and Judy try to prevent the relatives of a young boy who died of cardiac arrest finding out that he died in a brothel after having sex with another man. Robert tries to save the life of a base jumper whose parachute failed to open. Sam faces her worst nightmare when a young girl admitted following an overdose is found to have taken Plavitron. Ruth is furious when she discovers that Tessa has been unfaithful to her. Robert tells Christine that he intends to leave to take up a professorship in Edinburgh.
As it is Robert's last day, the rest of the team plan a surprise party for him. However, before he can take a sabbatical, he is forced to put all his efforts into saving a young boy who has been trapped inside a cold store. Sam informs James that her brother appears to have been part of the scam. Christine is disgusted to discover that Drummond plans to split A&E, making James head of a new minors department. In the heat of the moment, she agrees to marry Jack, but soon realises that she cannot be without Robert.
