Ananya’s family feels proud as she will be flying a plane for the first time as a pilot. Other pilots make fun of her for being a lady. Captain Qureshi welcomes the pilots and explains their duties. He introduces Ananya to the captain of the flight, Captain Verma. Captain Verma is happy with Ananya’s performance. During the flight, Captain Verma suffers a heart attack. Akash, a captain, tries to help Ananya, but she refuses his help and lands the plane safely.
Ananya is tensed about the enquiry committee meeting of the Pilots’ Association. The airport authorities become suspicious about a boy, Tahir. Ananya joins her second flight with Captain Vikas Rathod. A passenger, Payal, locks herself in the plane’s washroom. Ananya calms the passengers who panic on learning about the presence of a bomb in the plane. The airport police arrest Tahir. Payal reveals that she had spread the rumour about the bomb as she loves Tahir and wanted to reunite with him.
The Pilots’ Association instructs Captain Akash Saluja and Ananya that they have to fly together at least once in a week. Akash hides a gun in his shoes. Ananya helps an old lady, Mrs. Malik to board the flight. Mrs. Malik has an argument with a co-passenger. Ananya keeps Mr. Malik's ashes in the cockpit as per Mrs. Malik's wish. The police check the luggage of all the passengers for the stolen diamonds. Akash gets the thief, who had disguised as Mrs. Malik, arrested.
Few goons compel a Russian diplomat to deliver a package to Goa. The diplomat exchanges his luggage with that of Ananya’s, at the Goa airport. Later, Ananya realises that her luggage has been exchanged, and finds few bottles in it. Akash identifies the contents as drugs. Few goons attack Akash and Ananya. Akash and Ananya get the goons arrested and handover the drugs to the police. Mahima behaves in a suspicious way. Ananya thanks Akash for dropping the enquiry case.
Sangeeta decides to take a donor heart from Bhopal to Mumbai in a flight for the heart transplant of her husband. Meanwhile, the pilots' association goes on a strike. Hence, the connecting flight from Bhopal to Mumbai is cancelled. Sangeeta seeks Ananya's help. Ananya and Aakash decide to fly the flight to Mumbai, despite the strike. Captain Rathore instructs Aakash to abort the flight, but in vain. Sangeeta's husband undergoes a successful heart transplant.
Captain Vikas is upset with Ananya’s presence on his flight. Meanwhile, Akash and the airport authority are tensed after learning about Mahima’s suicide. Ananya suspects a female passenger to be ill. The passenger, Ratna, suffers from premature labour pain. Vikas orders Ananya to stay away from Ratna. Ananya requests Vikas to allow her to help the patient. A female passenger detects the delivery to be a breech baby. Akash covertly examines Mahima’s hotel room. Ratna gives birth to her baby.
Ananya learns about Mahima’s suicide. Karan denies his closeness to Mahima. Akash assures Mahima’s family that he will bring her body from Bengaluru and delivers on his promise.
Akash and Ananya fly into severe fog at Delhi Airport and find it difficult to land. In the interest of the passengers' safety, Akash redirects the flight to Jaipur. Due to scarcity of hotel rooms, the two share a single room. When Natasha learns this, she is upset.
When a security guard at the Jaipur airport holds Ananya and a few passengers hostage, Akash joins the rescue team. The guard sees Ananya make a phone call to aid the rescue effort and points the gun at her. Can Akash rescue Ananya?
Ananya and some of the passengers are held hostage by Manoj. Ananaya cleverly convinces Manoj to release the passengers. While Akash and the army trail Manoj, Ananya tries to convince him to surrender.
Rohit Mafatlal, the co-founder of Inde Airlines, carries a gun, fools the airport security and slips into a flight that has the Aviation Minister on board. Later, Natasha and Ananya are abducted. Rohit wants to deal with the problem in his own way. What does fate have in store for Natasha and Ananya?
Rohit boards the flight flown by Captain Vikas and Ananya. He disembarks at Aurangabad airport. The plane's engine catches fire mid-air and Rohit summons the senior pilots to resolve the crisis. How do Vikas and Ananya tackle the situation?
Ananya has her hands full as a replacement pilot. A couple arouses suspicion when Ananya sees the husband forcing his wife to consume banned drugs. Later, Ananya asks the co-pilot to inform the ACT about the husband. Will Ananya help the lady?
A disguised Aakash meets a friend. The pilot and the cabin crew suffer from food poisoning. Ananya has an obligation of landing the flight safe. Aakash gathers evidence about an anti-social activity. Will Ananya accomplish her task? Will Aakash fight against the misanthropic element?
Ananya is elated on learning that Aakash is back from his leave. Not wanting to put Ananya's life in danger, Aakash starts ignoring her. Rohit becomes furious at Aakash for not obeying his orders, and warns him. Later, Aakash is attacked by a few strangers. Who are the attackers?
Ananya admits Akash in the hospital. On regaining his conscience, Akash realises about his cover being blown. Meanwhile, a disguised doctor injects poison to Akash and kills two people during this act. Will the culprit be arrested?
Ananya stops Shefaali from committing suicide. Later, Rohit informs Ananya that he has recommended her for an interview. In the meantime, Kunal finds out that Ananya has Mahima's diary. Aakash vows to get hold of Mahima's diary. Will Aakash succeed?
Ananya shares her experience of being a pilot in an interview. Aakash replaces Mahima's diary with a similar one. An old man suffers cardiac arrest when the flight experiences an unexpected turbulence. What is the secret inside Mahima's diary?
Ananya is temporarily banned from flying an aeroplane. However, the enquiry committee acquits Ananya, based on the evidence produced by Rohit. Ananya resumes flying. Captain Aniket asks her to land the flight but she gets numb, recalling the past events!
Ananya is happy about her promotion as a Captain. Aakash suspects Rohit's life to be in danger. Rohit refuses to accept the vigilance agency's offer. He requests Ananya to fly an international flight. Aakash discovers that a terrorist, Babu is pretending to be Rohit. Will he avert the disaster?