Both Frida and Diego discover early on the forces that will shape their life’s work, but the legacies of their different upbringings will challenge their creative and romantic union. As a child Frida is struck with polio, which cripples her leg and leaves her bedridden. Then as a young woman, a terrible accident nearly takes her life. The pain and loneliness of these experiences haunt her artwork as an adult. Diego, on the other hand, finds joy in more tangible muses. As a toddler, he’s already creating murals, covering the walls of his home with chalk drawings of trains with cabin cars and cabooses. And by age six, he discovers the grand passion of his life, the one that will become his most enduring source of inspiration — and marital strife. Women.