女法醫官聶寶言(陳慧珊)父是拆彈專家,一次行動中卻意外被炸死,言化悲憤加入法醫行列,以繼承其父的遺志,捍衛社會公義。言的姐姐意(陳美琪),是著名的專欄作家兼電台節目主持,專替人解決家庭及愛情糾紛,惜能醫卻不自醫,與女兒津津(鍾麗淇)關係惡劣。
津偶然認識了在法證科工作的喬(魯文傑),喬曾涉嫌謀殺女友妮(陳彥行),津深信喬無辜,遂與言及喬兄原(林保怡)合力找出真凶,助喬洗脫罪名。津知他暗戀女CID蔡小棠(李珊珊),遂幫他追求之,卻發現小棠已心有所屬,喬無奈只好放棄。原與蔡在工作當中發生感情,而這時言也發現對原愛到不能自拔。
Tsung Ka Yuen is an excellent police officer whose team always seems to get assigned to the most interesting cases in all of HK. He works well with his police colleagues and is looked upon by everyone as the big brother. Ka Yuen is also very close to his dad, brother, and stepmom. Ka Yuen wife died from cancer and he hasn't dated anyone since. Later, Ka Yuen starts to like Pauline but before anything happens with her, he dates Siu Tong Choy, one of his colleagues.
Because the crimes that Ka Yuen's team deals with are mostly murders, in comes the forensics unit! The intelligent and modern forensics examiner, Pauline Lip Bo Yin. Her beauty and brains can be a bit intimidating so she too has not had much luck at love. As with Ka Yuen, Pauline also has an interesting family history. Her father was a well-known bomb expert who died when she was quite young. Pauline has remained extremely close with her mother, sister, and niece.