Why is it so hard to break free from the material reality we are locked into, as we perceive it? The default mode network within our brain, a recent discovery with ancient implications, locks our minds into material reality and blocks access to spirituality and alternate planes of consciousness. The key to breaking free of this ancient matrix may be found with the careful use of psychedelics. Studies show that we can regulate this default mode network with meditation and exercise. But plant medicines may offer the breakthrough we need to shut down the predictive coding embedded within our brains. This would help us release the old stories that we impose upon new situations we encounter and help us to perceive the world in more beneficial ways.