The history of Immunology could started as early as 2000 years ago in China. But it took hundreds of years for Immune-Medicine to be researched properly in Europe. Epidemics like the Black Death usually had it pretty easy in human history: A lack of understanding and missing hygiene were an ideal breeding ground. That changed fundamentally during groundbreaking discoveries in the 19th century. Robert Koch and his students’ paved the way for modern medicine and vaccination research.