The wicked multi-billionaire, Shinatora, builds wretched, ugly buildings. The explosives genius calling himself Benten has targeted Shinatora's empire and begins to destroy the monstrosities that are wiping out whole sections of downtown Tokyo. In cooperation with the local police force, the FBI has sent Lisa Hoshino, a bomb disposal expert, and her robot assistant, Dandy, on a lecture tour of Japan. Ryotsu is reluctantly paired with Lisa to protect the people of the Kameari district. Why does Benten only target Shinatora's buildings? What is his next target?
Another email warning arrives at the Katsushika Police Station. Benten's next target is the newly built, gigantic amusement park, Shinatora World. Lisa and Ryotsu hurry to the scene. What they find is a huge Soviet-era rocket armed with a massive bomb powerful enough to obliterate the entire area of Katsushika.
亀有に出現した謎の爆弾犯をめぐり、おなじみ両さんたち派出所メンバーの活躍を描く。ともさかりえが声を演じた爆弾処理班などの新キャラに加え、破天荒な両さんが映画版ならではのスケールで大暴れ。お馴染みの浅草をはじめ、上野、銀座と実際の街並みを活写した美術も見どころ。品田虎三が経営するシナトラホテル、顧問弁護士マーティン率いるシナトラ商会の悪趣味なビル群が次々と爆破された。犯人は、弁天小僧と名乗る謎の爆弾プロ。葛飾暑にはFBIから爆弾処理のエキスパート・星野リサと、パートナーのロボット・ダンディが派遣される。嫌々ながらもリサとコンビを組んで捜査にあたる両津。そんな時、葛飾暑に弁天小僧から新たな犯行予告が届く。
