During a Mardi Gras parade in New Orleans, a girl becomes the latest victim of the deadly virus "XB". Dr. Clinton Earnshaw (Sam Groom) has been following the outbreak but only is able to diagnose it. The federal government assigns him Jeff Adams (Tom Hallick), who has no medical or scientific training. Though Earnshaw is initially bemused by the assignment, Adams' value emerges when he remembers the 19th century discovery of a virus with similar characteristics. Known at the time as "Wood's Fever", it was discovered by Dr. Joshua P. Henderson (Richard Basehart). Both men know that Henderson's notes were destroyed in the 1871 Great Chicago Fire, his only remaining artifact a gold pocket watch.
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