William Fitzgerald (Richard Derr), the lone survivor of a shipwreck, washes ashore on Blood Island. He is found by Dr. Charles Girard (Francis Lederer), a scientist who has set up a laboratory on the isolated island with his disenchanted wife, Frances (Greta Thyssen), and his assistant Walter Perrera (Oscar Keesee). The island's natives fear Dr. Girard, as he has been experimenting on a panther, surgically changing it with a series of painful operations into a half-man/half-panther beast which occasionally escapes from its cage and kills an unwary villager. The creature is swathed in bandages, but his cat-like eyes and ears are still evident. The creature is attracted to Frances, as she is the only person on the island who shows him pity.
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