Patricia Porker (Erin Brown) is a shy New Jersey high school girl whose life is changed forever when she is bitten by a genetically-engineered spider and turns into a wall-climbing beauty with superhuman strength. Calling herself SpiderBabe, she uses her newfound powers to enter a wrestling contest and win enough money to move out of her Uncle Flem and Aunt Maybe's home and into her own apartment with best friend Lisa Knoxx (Darian Caine). However, a robber murders Uncle Flem and inspires Patricia to use her newfound powers to battle crime in New York City, while she also tries to tell her best friend Mark Wetson that she wants to be his girlfriend and has copious amounts of lesbian sex. Meanwhile, Lisa's ambitious sister, Lucinda Knoxx (Suzy McCoppin), uses the same genetic engineering techniques that Patricia's science teacher, Dr. Dowell (Michael R. Thomas), had used on a spider on herself, and gains a villainous alter-ego, the sexy and evil genius '''Femtilian'''. Femtilian sets out on a quest for world domination that can only be resolved in a head-to-head showdown with SpiderBabe.
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