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Set in an affluent neighborhood of the San Fernando Valley in 1987, the film recounts the life of a seemingly unremarkable homemaker, Carol White (Julianne Moore) who develops multiple chemical sensitivity (MCS, also known as "Twentieth-Century Disease"). MCS is a medically controversial diagnosis in which a person develops mild to severe non-specific symptoms and believes that these symptoms are triggered by chemicals found in everyday household and industrial products.

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