Chris Hammond is a high school senior. He likes a girl at school (Laurie) who happens to be dating his rival and bully Rick. His father, Jack, is a surgeon and working hard to get a promotion to the position of the chief of staff at his hospital. He also wants his son to become a doctor as well, but Chris is not interested. Chris's friend, Clarence "Trigger", has an uncle Earl who had been bitten by a snake whilst in the desert. Earl had his leg fixed by Native Americans with a body-switching potion called the "Brain-Transference Serum." Trigger shows Chris how the Brain-Transference Serum works by trying it out on Chris' cat and dog, and the pets switch bodies. Trigger brought the Brain Transference Serum in a Tabasco sauce bottle, and the Hammond's housekeeper Phyllis finds the bottle and puts it in the food cupboard. Jack unwittingly puts it in his Bloody Mary. The serum works by someone ingesting it, then the next person that looks into their eyes switches bodies with them. As Jack looks into his son's eyes while having a disagreement over a C grade on an important test, the father and son switch bodies.
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