Ana and Anny live, along with their deformed brother/son, in the desolate southern Chilean countryside, after having been sheltered from society by their drug dealer father for their entire lives. One day the police come calling to investigate, and after bullets are fired and chainsaws are revved up, the three siblings find themselves on their own, and on the road. But the trio is also on the run from their father’s crazed drug kingpin boss Uncle Costello, who is convinced the sisters know where his valuable supply is hidden. He sends an army of trained killers to track them down... but Costello and his gang find that they might be in for more than they bargained for, and amidst a world of bloody executions, roadside prostitution, sexual assault, and even cannibalism, the bodies keep on piling up.
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