Connie (Nia Vardalos) and Carla (Toni Collette) are two performers whose lifelong friendship and co-obsession with musical theater have brought nothing but career dead ends. Despite this they continue their optimism, hosting a variety act at an airport lounge. After accidentally witnessing a mafia hit in Chicago, they go on the run, landing in Los Angeles. After being fired from a beauty salon, they pose as drag queens and audition to host a drag revue at a gay club called "The Handlebar."
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