Alex Mathis (Greg Grunberg) is a cash-strapped but good-natured exterminator working in Los Angeles. While helping an elderly woman with a rodent problem, he is bitten by a poisonous spider and is treated at a hospital. Meanwhile, a mortician is bitten by a rodent-sized spider that crawls out of a dead body which just arrived at the hospital. Learning of this, Alex offers to take care of the spider in exchange for clearing his hospital bill. José Ramos (Lombardo Boyar), a hospital security guard, offers to help Alex. Going to the morgue, Alex deduces the spider escaped into an air vent. He enters the vent and communicates with José via walkie-talkie. Meanwhile, a military task force led by Major Braxton Tanner (Ray Wise) and Lieutenant Karly Brant (Clare Kramer) show up at the hospital to examine the dead body the spider burst out of.
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