A Douglas DC-3 piloted by Bill Lonagan (Robert Ryan) and Joe Brooks (Keith Andes) is bound for Boca Grande, South America, making a pick-up stop in Central America. The passengers are: Jud Ellis (Gene Barry), escorting his fiancée Louise Melhorn (Phyllis Kirk); repentant political assassin Vasquel (Rod Steiger) being transported back to the proper authorities by detective Crimp (Fred Clark); mobster Pete Bostwick (Jesse White (actor)), accompanying a little boy named Tommy, whose father is Bostwick's boss; an elderly couple, Professor and Mrs. Spangler (Cameron Prud'Homme and Beulah Bondi), apparently on vacation; and jilted blonde bombshell Rena (Anita Ekberg), on her way to a South American casino and vying for Ellis' attention.
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