The Re-Animator film series is based on the 1922 short story Herbert West–Reanimator by H. P. Lovecraft. With their quirky sense of humour and off-the-wall gore, they soon became cult classics.
At University of Zurich Institute of Medicine in Switzerland, Herbert West brings his dead professor, Dr. Hans Gruber, back to life. There are horrific side-effects, however; as West explains, the dosage was too large. When accused of killing Gruber, West counters: "I gave him life!"
Eight months after the events of ''Re-Animator'', doctors Herbert West and Dan Cain are working as medics in the middle of a bloody Internal conflict in Peru. In the chaos of battle and with plenty of casualties to work on, they are free to experiment with West's re-animation reagent. When their medical tent is stormed by the enemy troops, West and Cain return home to Arkham, Massachusetts. There, they resume their former jobs as doctors at Miskatonic University Hospital, and West returns to the basement laboratory of Cain's house to continue his research.
For the past 13 years, Herbert West (Jeffrey Combs) has been serving a prison sentence due to a murder at the hands of one of his zombies. With what scant supplies he has on hand in the prison medical center, Dr. West has been capable of performing only extremely basic experiments on rats. However, his lack of supplies does not prevent him from uncovering a key element in his re-animation process. Dr. West has discovered "NPE" (Nano-Plasmic Energy), an energy that can be extracted from the brain of a living organism through an electrocution-like process, to be stored in a capsule resembling a small light bulb. The capsule can then be connected to a corpse and used in conjunction with West's previously developed reagent to restore the former dead to a lifelike state. The NPE prevents the degeneration seen in previous instances, where the reanimated are nothing more than mindless zombies. Used together with the re-agent, reanimated corpses regain their skills, memories, and motor functions and nearly fully resemble normal humans.